In the Spring of 1996, Founding Monarch Melissa Jo Murchinson-Blake was in search of sisterhood. She wanted to be a part of a family that openly embraced all women and crossed cultural boundaries. As a bi-racial woman, she did not want to choose between historically Caucasian or African-American sororities. Found Monarch Murchison-Blake felt that if she did choose one, she would be denying half of her heritage.

Still wanting to be a part of a strong sisterhood, Founding Monarch Murchison-Blake recruited six oter women to join hands in her quest to found Theta Nu Xi Multicultural Sorority, Inc. At first, the Founding Monarchs were discouraged from fulfilling their vision. The Director of Greek Affairs advised them to consider joining an exising organization, expressing his concern that a new Greek organization, based on the principle of multiculturalism, would not survive at UNC-CH. However, the Founding Monarcs believed there was a need for such a sisterhood. Their efforts set the stage for Theta Nu Xi's presence in the Greek, Non-Greek, and surrounding communities.  

After much work and dedication, the Founding Monarchs built the foundation for Theta Nu Xi. Finally, the University of North Carolina at Chapel Hill officially recognized Theta Nu Xi Multicultural Sorority as the Alpha Chapter on April 11,1997. With the collaborative efforts of the Founding Monarchs and the Sisters of Spring 1998, the organization grew beyond our expectations. The Sorority Incorporated on April 29, 1999. And, with the particiaption of the Alpha Chapter and Beta and Gamma Colonies, the National Organization was founded at the first annual National Convention on August 21,1999.